Process of making an organic mercury compound



Patented Apr. 21, 1931p i I UNITED STATES PATENT OFFICE EMIL SCHEITLIN, OF BASEL, SWITZERLAND PROCESS OF MAKING AN ORGANIC MERCURY COMPOUND No Drawing. Application filed November 19, 1928, Serial No. 320,536, and in Germany November 23, 1927.

My invention refers to a method'of making plex mercuric compound free from mercuro an organic mercury compound being adapted compounds. for use as a remedy.

I have found that l-phenyl-2,3-dimethyl-4=- 5 sulfamino-5-pyrazolon if combined with a 7 grams 1-phenol2,3-dimethyl-4-sulf- 55 mercuric salt forms complex compounds amino-5-pyrazol0n are dissolved in 100 which contain 1 atom mercury to 4 molecules ccms. water. 2.7 grams mercuric oxide are pyrazolon, these complex compounds being dissolved in 10 to ccms. water to which particularly adapted for therapeutic use as havebeen added 2.5 ccms. sulfuric acid of 10 they'possess a great spirillocide action and 66 Be. These two solutions are mixed at are readily soluble in physiological salt ordinary temperature or at least at a tempersolution. ature not exceeding 50 C. After, standing The processes hitherto known for prepara while this mixture separates out crystals, ing mercury compounds of the pyrazolon which are separated from the mother liquor 15 series resulted in compoundsof an altogether and dried. The compound is white colored, different character. Thus by acting at an it contains 17,617,7 per cent mercury and is elevated temperature with mercuryoxide onsoluble in dilute caustic soda, in hydrochloric a watery solution of 1- h ny1-2,3-di th 1 4- acid and in physiological salt solution. On sulfamino-5-pyrazolon there was bt in d a heating the compound melts under decompo- 20 white crystalline body insoluble in water and SitiOIl, w d-' Still h g p raother solvents. tures it will char. In concentrated sulfuric If the water-soluble salts of 1-ph ny1-2,3- acid the compound dissolves under decompodimethyl-4-sulfamino-5-pyrazol0n were treat- .sition. In alcohol, ether and the usual ored at an elevated temperature with bivalent ganic $01VBIltS is it iI1$01llb1emercury salts, there resulted a greenish P chwges y be m in the F powder containing 6768 per cent mercury, fi dlsclosed the foregolngspeclficatlon for the major part in the form of a lower h i departlng from the lnventlon i. -1 sacrific ng the advantages thereof.

According to the present invention mer- I 31mm cury and sulfuric acid are caused to act at The method of producntglan orgimlc ordinary temperature on a watery-solution of fi of mfmury compnsmg actmg on lon. There result white crystals containing 3 a fi i 1 t 3 3? 17 ,6 per cent mercury. The compound is bee 0 Su unc acl W1 mercurlc 0X1 6 Example 35 latter acting as sulfate in the process. heved to have the formula In testimony whereof I affix my signature.

05H 0 EMIL SGHEITLIN.

I 5 m 5H5 I N 3 N 40 CHFN/ co o=o \N-CH3 g It is soluble in physiological sodium chloride solution and if an alkali is added no precipitation occurs. This shows that the compound resulting in the reaction is a pure com- 10G 

